Susten 200mg Injection (Progesterone)

Susten 200mg Injection (Progesterone) – Product Information

Brand Name: Susten
Generic Name: Progesterone
Type: Injectable form of synthetic progesterone
Class: Hormone Replacement Therapy (HRT)

Introduction

Susten 200mg Injection contains Progesterone, an essential hormone to regulate the menstrual cycle as well as pregnancy. Progesterone that is injected is used to treat various issues related to hormone imbalances. This includes amenorrhoea, luteal phase insufficiency, in addition to the use of progestin supplements within assisted reproductive technology (ART). Also, it is prescribed in conjunction with the hormone treatment (HRT) for postmenopausal women.

Progesterone plays a vital role in ensuring that pregnancy continues and in prepping your endometrium (the lining of the uterus) for embryo implantation. Susten 200mg Injection is commonly employed in clinics to aid in the support of pregnancy for those who are undergoing fertility treatments or suffer from progesterone deficiency.

Composition

• Active Ingredient: Progesterone – 200 mg per 1 ml
• Excipients:
  • Polysorbate 80
  • Sesame oil
  • Benzyl alcohol (preservative)

The medication is typically sold in ampoules with the equivalent of 1ml, which will be administered by a medical expert.

Indications

Susten 200mg Injection is typically used to treat the following ailments:

• Hormonal Imbalances:
  It’s used to treat primary amenorrhea (absence of menstrual cycle) as well as deficiency of the luteal stage (insufficient progesterone levels following ovulation) and other conditions that impact fertility.
• Infertility Treatment:
  Progesterone is an essential hormone for supporting the process of pregnancy development. Susten 200mg can be combined with fertility medications to support the process of implantation as well as early pregnancies, especially in women who undergo in vitro fertilization (IVF) or other assisted reproductive methods.
• Prevention of Miscarriage:
  The women who experience recurrent miscarriages because of insufficient progesterone levels may be treated with Susten to help maintain a pregnant woman in the early stages of her pregnancy.
• Postmenopausal Women:
  A part of the hormone replacement therapy (HRT), Susten can be prescribed to postmenopausal women to ease the symptoms of hot flashes and night sweats and also to safeguard the endometrium against overstimulation resulting from the estrogen treatment.
• Endometriosis:
  The drug can also be used to treat endocrine disorders, in which the tissue of the uterus develops beyond its normal size, which leads to discomfort and other signs.

Mechanism of Action

Progesterone, the primary component in Susten 200mg Injection, is akin to the hormone that is naturally produced; progesterone is vital to regulate the menstrual cycle as well as maintain pregnancy.

• Support for Pregnancy:
  Progesterone is a hormone that prepares the endometrium to allow for the birth of fertilized eggs. Additionally, it helps to maintain the inner lining of the uterus, stopping early miscarriage and aiding in the continued success of the pregnancy.
• Endometrial Protection:
  When women are prescribed estrogen in conjunction with HRT, progesterone can be utilized to reduce the danger from Endometrial Hyperplasia (overgrowth within the lining of the uterus) and can increase the chance of developing cervical cancer of the uterus.
• Menstrual Regulation:
  For conditions such as secondary amenorrhea, the hormone progesterone can help control the menstrual cycle. It also helps to regulate menstrual bleeding.

Dosage and Administration

• Standard Dosage:
  The standard dosage of Susten 200mg Injection will be 200 mg twice a each day and administered via injection intramuscular (IM) injection. The frequency and dosage may be different depending on the disease being treated, as well as the specific needs of the patient.
• For Fertility Treatments:
  • Luteal Phase Support: In ART, injections of progesterone can be administered to women who’ve had procedures such as IVF and embryo transfers in support of the pregnancy.
  • Miscarriage Prevention: If a woman has previous miscarriages that have recurred, Susten may be administered at any point from the beginning of pregnancy (around the six-week mark) through at least the 12th week of gestation.
• For Amenorrhea:
  An average regimen could involve giving 200 mg Susten 2 – 3 times per week during a specific time in order to stimulate menstruation and to restore the hormonal balance.
• In Postmenopausal Women (HRT):
  The dose of Susten could vary according to the dosage of estrogen used. Susten is usually administered on the basis of a cycle, usually during the last 12-14 days of the month-long cycle.
• Administration:
  Susten 200mg can be administered by the medical expert via the use of an intramuscular injection (IM). It is typically administered to the upper extremity of the buttocks.

Contraindications

Susten 200mg injection should not be administered to those who:

• Do you have an identified allergy to progesterone or any of the other excipients (e.g., polysorbate 80 or sesame oil).
• Have a history of blood clots, stroke, or other thromboembolic disorders.
• Have a history of breast cancer, endometrial cancer, or other hormone-dependent cancers.
• Have liver disease or active liver dysfunction.
• Have unexplained vaginal bleeding.
• Are pregnant without medical supervision (except in certain instances, progesterone supplements are required for IVF or to prevent miscarriage).

Precautions

• Cardiovascular Health:
  Progesterone can increase the chance of thromboembolic events (blood clots), and therefore, those with a previous history of heart disease, deep vein thrombosis, or an embolism in the pulmonary vein should take the medication cautiously.
• Liver Function:
  It is important to exercise caution for patients suffering from liver issues because progesterone is processed through the liver, and the liver’s dysfunction can affect the effectiveness of progesterone.
• Breast Cancer Risk:
  A long-term usage of hormone treatments such as progesterone may cause a minor rise in the likelihood of developing breast cancer, particularly when there is a personal or familial background of breast cancer.
• Pregnancy:
  Although Susten 200mg is frequently employed in the first stage of pregnancy to aid the growth of the fetus, it should be administered under the supervision of a health professional, as well as in conjunction with a medication program.
• Monitoring:
  Monitoring of the liver’s function regularly, blood pressure, liver function, and the signs of blood clots might be needed during the treatment of progesterone.

Side Effects

The most frequent side effects that can be attributed to Susten 200mg Injection could include:

• Injection Site Reactions: Pain, redness, or swelling at the site of injection.
• Headache: An often-repeated side effect linked to hormonal changes.
• Mood Changes: Depression, irritability, or mood swings.
• Dizziness or Fatigue: It can happen, particularly in the first few days of the treatment.
• Nausea or Vomiting: Women may experience nausea following an injection.
• Breast Tenderness: Due to hormonal changes.

The most serious, but rare negative side effects could be a result of:

• Blood Clots: Symptoms like leg swelling, pain, redness, or shortness of breath require immediate medical attention.
• Liver Dysfunction: Symptoms of liver problems include jaundice (yellowing of skin/eyes), dark urine, or abdominal pain.
• Breast Lumps or Pain: All unusual changes to your breasts are to be reported immediately to your physician.

If you are experiencing any serious adverse side effects, consult your doctor immediately.

Drug Interactions

Susten 200mg Injection can be incompatible with a variety of medicines, for example:

• Anticoagulants (blood thinners): Like warfarin, progesterone could increase the chance of blood clots.
• Corticosteroids: Combining use can intensify the effects that come from both drugs.
• Anticonvulsants (e.g., phenytoin, carbamazepine): This can decrease the effectiveness of progesterone.
• Other Hormonal Medications: Like estrogen and other progestins. These could result in unwanted undesirable side effects, or reduce the efficiency when taken in conjunction with Susten.

Make sure you inform your physician of any medication or supplement that you’re currently taking.

Overdose

A high dose of Susten 200mg injection can trigger the following symptoms:

• Severe dizziness or fainting
• Abnormal bleeding or spotting
• Nausea or vomiting

In the event of a suspected overdose, the immediate assistance of a medical professional must be sought.

Storage Instructions

• Store at room temperature (15–25°C).
• Store the ampoules inside the original container to shield them from the sun’s rays.
• Make sure that the area is safe for young children.
• Use the injection only within the time frame of the expiration date printed on the package.