Vitilex 50mg (Levamisole)

Vitilex 50mg Tablet (Levamisole) – Product Information

• Brand Name: Vitilex
• Generic Name: Levamisole
• Strength: 50 mg
• Dosage Form: Oral Tablet
• Manufacturer: Glowderma Labs Pvt Ltd
• ATC Code: P02CE01

Product Description

Vitilex 50 mg Tablet is an antihelmintic drug that contains levamisole as its active ingredient. Levamisole is an imidazothiazole derivative synthesized in a laboratory with broad-spectrum antibacterial properties against various parasite infections. It’s used primarily for treating roundworm (ascariasis) as well as hookworm (ancylostomiasis) diseases. In addition, levamisole is known to have immune-modulatory properties. It has also been utilized as an addition to treatment for cancer, especially for colon cancer, to increase the effectiveness of chemotherapy.

Mechanism of Action

Levamisole works by binding to nicotinic Acetylcholine receptors located within the muscles of nematodes, which causes depolarization and, eventually, in turn, paralysis of the parasites. The paralysis hinders the worms’ capability to hold their positions in the intestines and leads to their removal via peristalsis. The immunomodulatory properties of Levamisole are due to its capacity to boost T-cell function as well as stimulate the creation of interleukins and thereby improve the body’s immune response.

Indications

Vitilex 50 mg Tablet is indicated for:

• Ascariasis: The roundworm is the cause of infection. Ascaris Lumbricoides.
• Ancylostomiasis: Hookworms are the cause of infection, mostly Ancylostoma duodenale and Necator americanus.
• Mixed Ascariasis-Hookworm Infections: Co-infection of roundworms as well as hookworms.
• Adjunct in Cancer Therapy: As an aid to treat colon cancer, it can enhance the effectiveness of chemotherapy.

Dosage and Administration

• Ascariasis and Ancylostomiasis: A typical adult dosage is 2.5 mg/kg body mass, taken as a single dosage. In the case of children, the dosage is adjusted in accordance with the weight of the body.
• Mixed Infections: Dosing schedules can vary. Consult a physician for the proper dosage.
• Adjunct in Cancer Therapy: Levamisole is a drug that can be administered with chemotherapy drugs. The dosage schedule is decided by the oncologist in accordance with the chemotherapy regimen that is specific to the patient.

Administration: Drink the tablet completely with the help of a glass of water. Don’t chew, crush, or smash the tablet. It is able to be taken in conjunction with and without meals.

Contraindications

Vitilex 50 mg Tablet is contraindicated in:

• Hypersensitivity: A known allergy to levamisole or any of the tablets’ ingredients.
• Severe Renal Impairment: People with severe kidney impairment are advised to avoid this drug as it could cause the accumulation of toxins and possible toxicity.
• Severe Liver Impairment: Be cautious when using this medication in patients suffering from liver disease. Dosage adjustments might be needed.

Warnings and Precautions

• Blood Disorders: Levamisole is known to cause Agranulocytosis (a drastic diminution in the white blood cell count), which can increase the risk of contracting infections. Monitoring of blood count regularly is advised during extended treatment.
• Immunocompromised Patients: Take care when treating people with weak immune systems.
• Pregnancy and Lactation: Levamisole isn’t recommended for lactation and pregnancy unless possible benefits outweigh the risk to the fetus and baby. Talk to a physician before taking.
• Drug Interactions: Levamisole could interfere with other drugs, such as immunosuppressants or chemotherapy agents. Tell your physician of any medications you’re using.

Adverse Reactions

Common side effects include:

• Gastrointestinal: Nausea, vomiting, abdominal pain, diarrhea.
• Central Nervous System: Headache, dizziness, fatigue.
• Skin: Rash, itching.

Serious side effects may include:

• Hematologic: Agranulocytosis, thrombocytopenia.
• Hepatic: Elevated liver enzymes, jaundice.
• Neurological: Seizures, confusion.

If serious adverse side effects are observed, stop the use immediately and get medical assistance.

Storage and Handling

• Storage Conditions: Keep at room temperature between 20°C and 25°C (68°F to 77°F). Be sure to protect yourself from the sun and water.
• Handling: Make sure that the tablet is out of reach for young children. Avoid using the tablet if it has been damaged or is expired. Do not dispose of any medicine that isn’t used as per local rules.

Packaging

Vitilex 50 mg Tablet is sold in the following packages:

• 4 Tablets per Strip: Ideal for short-term therapy courses.
• Bulk Packaging: Accepted for use by institutions. Ask the manufacturer for bulk-order specifics.

Pricing and Availability

• Price: About $18 (AUD $25.21) for a strip of 20 tablets.
• Availability: The drug is sold at the top pharmacies and on online platforms such as modalertaustralia.com.

Patient Counseling Information

Patients must be aware of the following aspects:

• Proper Use: Follow the directions for taking the tablet from your physician. Never alter the dosage or cease use of the tablet without consulting your physician.
• Monitoring: A regular blood test may be necessary to detect potential adverse effects, particularly when undergoing long-term therapy.
• Side Effects: Be aware of possible adverse reactions and notify your doctor.
• Drug Interactions: Tell your doctor about any medications you’re taking to ensure you avoid any interactions.

Conclusion

Vitilex 50 mg Tablet is a highly effective antihelmintic medicine for treating hookworm and roundworm infections. Its properties to modulate the immune system make it an effective adjunct to cancer treatment. Similar to all drugs, they should be administered under the direction of a medical professional for safety and effectiveness.