Susten SR 300mg (Progesterone)

Susten SR 300mg (Progesterone)

Brand Name: Susten SR
Generic Name: Progesterone
Strength: 300 mg
Form: Sustained Release Tablet
Manufacturer: Sun Pharmaceutical Industries Ltd.

Overview

Susten SR 300mg is a medicine that contains Progesterone, which is a hormone that plays an important function in controlling the menstrual cycle and pregnancy as well as the general well-being of females. Susten Sr is a prolonged-release version of progesterone that is designed to give a steady and consistent release of the hormone throughout the course of time, which ensures stable blood levels. Susten SR is used primarily in the treatment of hormone deficiency (HRT) as well as for ailments that are caused by progesterone deficiencies.

Indications

• Hormone Replacement Therapy (HRT): Susten SR 300mg is typically used in conjunction with estrogen for postmenopausal women who have a healthy uterus. This combo helps to protect against the development of endometrial hyperplasia (thickening of the lining of the uterus) and is a risk factor for developing the development of cancer in the uterus.
• Secondary Amenorrhea: It is used for treating secondary amenorrhoea (absence of menstrual flow) resulting from the deficiency of progesterone.
• Luteal Phase Support: A lot of times, it is used in assisted reproductive technology (ART), such as in vitro fertilization (IVF), to aid in the luteal phase of menstrual flow as well as increases the odds of a successful pregnancy.
• Prevention of Miscarriage: In certain cases, Progesterone supplementation using Susten is a possibility to avoid repeated miscarriages due to progesterone deficiencies in the early stages of gestation.

Mechanism of Action

Progesterone is a naturally-occurring hormone that has a key role to play in the regulation of various phases of menstrual flow as well as supporting pregnancy. Susten SR delivers progesterone in a continuous release way; that is to say, its absorption is gradual in the course of.

• In the Menstrual Cycle: Progesterone assists in preparing the endometrium (lining of the uterus) to allow the birth of fertilized eggs. It also assists in maintaining a healthy environment during early pregnancies.
• During Pregnancy: Progesterone helps to stop the uterus from contracting and thus causing premature labor. It also aids in the growth of the fetal condition.
• In Hormone Replacement Therapy (HRT): Together with estrogen, progesterone can help balance estrogen’s effects and decrease the chance of endometrial hyperplasia. It may occur when estrogen alone is employed.

Dosage and Administration

• Standard Dosage for Hormone Replacement Therapy (HRT):
  • 300 mg daily of Susten SR (usually given at night).
  • Most commonly, it is taken for 10- 14 days per month based on the prescribed regimen by your doctor.
• Dosage for Secondary Amenorrhea:
  • 300 mg daily for five to ten days per prescription to begin the menstrual cycle.
• Dosage for IVF or Assisted Reproductive Technologies (ART):
  • 300 mg per day can be administered in the beginning, following the retrieval of eggs or ovulation, continuing through the first stages of pregnancy, to aid in the function of the luteal stage.

Administration Instructions:

• Consume just one tablet each day, usually at night, to reduce dizziness and drowsiness that can occur during the day.
• Take the tablet as a whole and drink it with the help of a glass of water.
• It may be consumed either with or without food, but taking it along with food could help to prevent stomach discomfort.
• Don’t smash or chew the sustained-release tablet since this can alter the control mechanism.

Contraindications

• Hypersensitivity to Progesterone or Excipients: People who have a history of an allergy to progesterone or any other active ingredients contained that are contained in the tablet must not make use of Susten SR.
• History of Hormone-Sensitive Cancers: Don’t use the product if you have a previous history or a previous history of breast cancer or similar estrogen-dependent cancers.
• Untreated Endometrial Hyperplasia: It is not recommended to use this method for patients who have not been diagnosed with vaginal bleeding abnormalities or endometrial hyperplasia.
• Active or History of Thromboembolic Disorders: Susten SR is not recommended when patients have a previous history of deep vein thrombosis, pulmonary embolism, or any other thromboembolic disorder.
• Severe Liver Dysfunction: Not recommended for patients suffering from significant liver disease.
• Pregnancy and Breastfeeding: Susten SR is typically not advised during pregnancy unless it is absolutely required it is prescribed, it should be used with care. Susten SR is not suggested when breastfeeding.

Warnings and Precautions

• Cardiovascular Risk: Progesterone could increase the chance of the thromboembolism of the venous vein particularly in those who have a history of bleeding or risk factors. It is recommended to be cautious with these patients.
• Endometrial and Breast Cancer Risk: The long-term treatment with hormones such as progesterone can increase the chance of developing the endometrial tumor (if it is not taken together with estrogen) as well as Breast cancer. Monitoring and screening on a regular basis is advised.
• Liver Function: Patients suffering from liver problems must take this medicine cautiously, since progesterone metabolism is controlled by the liver.
• Depression: Progesterone could cause mood fluctuations that include mood swings, such as depression or anger. If symptoms of these occur, you should consult your physician.
• Blood Pressure: Keep track of blood pressure on a regular basis since high doses of progesterone can cause changes to blood pressure.

Adverse Effects

The majority of patients can tolerate Susten SR 300mg fairly well. However, like every medication, side effects are possible. Here are some of the most common side effects, which are serious:

Common Side Effects:

• Drowsiness or dizziness (especially when taken at night)
• Headache
• Nausea or mild gastrointestinal discomfort
• Breast tenderness
• Mood changes (such as irritability or depression)
• Weight changes
• Fatigue

Serious Side Effects (Seek Immediate Medical Attention):

• Severe abdominal pain or swelling
• Jaundice (yellowing of the skin or eyes)
• Unusual vaginal bleeding
• Leg pain, swelling, or redness (which could indicate deep vein thrombosis)
• Shortness of breath or chest pain (which could indicate a blood clot or pulmonary embolism)
• Signs of a stroke (sudden numbness or weakness, confusion, trouble speaking or seeing)

Drug Interactions

• Estrogen Therapy: When used in conjunction with estrogen in HRT, the dosage of progesterone might have to be adjusted.
• CYP3A4 Inhibitors: Medicines that hinder the activity of CYP3A4 (such as ketoconazole, ritonavir, and certain antibiotics) may increase the levels of progesterone, which can increase the chance of adverse effects.
• Anticonvulsants and Rifampin: The drugs can lower progesterone levels by raising its metabolism and possibly decreasing its effectiveness.
• Other Sedatives and CNS Depressants: Progesterone is known to cause drowsiness; it is recommended to exercise caution in conjunction together with other sedatives, tranquilizers, and alcohol.
• Blood Thinners: It is important to be cautious when you take blood thinners since the combination can raise the risk of bleeding clots.

Storage

• Storage Instructions:
  Store Susten SR tablets at room temperatures (between 20°C to 25°C, or 68°F to 77°F).
  Place the medicine in a dry location far from moisture and light in order to ensure its effectiveness.
  Be sure to keep the tablets away from the reach of young children.

Packaging

• Tablet Count: Susten SR 300mg can be purchased in blister packs that contain either 10 or 30 tablets.
• Packaging Type: Tablets are packed in blister packs that are protected in order to protect their effectiveness and stability.

Frequently Asked Questions (FAQs)

What is Susten SR 300mg used for?

Susten SR 300mg can be used mostly as part of hormonal replacement therapy (HRT) for treating menopausal symptoms, as well as to treat conditions such as primary amenorrhea, luteal phase aid in IVF, and to prevent pregnancy loss because of progesterone deficiencies.

How should I take Susten SR 300mg?

It is recommended to take one tablet each day, usually at night. The tablet can be consumed in conjunction with food or not, but must be taken whole with no chewing or crushing the tablet.

What should I do if I miss a dose?

If you are unable to take the dose, you should do it as quickly as you can remember. When it’s almost time for your next dose, you can skip the dose you missed- make sure you don’t have two doses in a row.

Can Susten SR be used during pregnancy?

Susten SR can typically not be utilized in pregnancy except as directed by a physician. Susten is often utilized to avoid miscarriage in those with deficiency in progesterone; however, it is best to use it under the supervision of a medical professional.

Are there any serious side effects of Susten SR?

Some serious side effects can result in intense abdominal discomfort, yellowing of the skin (jaundice), or breast lumps. If you notice one of these signs, get medical attention right away.